After sleeve gastrectomy, which medication should be avoided due to risk of anastomotic ulcers?

After sleeve gastrectomy, which medication should be avoided due to risk of anastomotic ulcers?

• A. NSAIDs
• B. Acetaminophen
• C. Ibuprofen
• D. Aspirin

Answer: (A)

Nonsteroidal anti-inflammatory drugs should be avoided after sleeve gastrectomy because they raise the risk of anastomotic ulcers. NSAIDs inhibit COX enzymes, which decreases prostaglandin production. Prostaglandins help protect the gastric mucosa and promote healing at the surgical staple line. With reduced protective factors and impaired healing, the gastric tissue at the anastomosis becomes more susceptible to ulceration. Acetaminophen, by contrast, provides analgesia with minimal GI mucosal risk, so it’s the preferred option for pain after this surgery.

Nonsteroidal anti-inflammatory drugs should be avoided after sleeve gastrectomy because they raise the risk of anastomotic ulcers. NSAIDs inhibit COX enzymes, which decreases prostaglandin production. Prostaglandins help protect the gastric mucosa and promote healing at the surgical staple line. With reduced protective factors and impaired healing, the gastric tissue at the anastomosis becomes more susceptible to ulceration. Acetaminophen, by contrast, provides analgesia with minimal GI mucosal risk, so it’s the preferred option for pain after this surgery.