ALS clinical manifestation?

ALS clinical manifestation?

• A. Symmetric proximal weakness
• B. Asymmetric leg weakness
• C. Facial weakness
• D. Sensory loss

Answer: (B)

ALS often presents as a motor neuron disease with weakness that starts in one area and is not symmetric. The most typical early pattern is asymmetric limb weakness, commonly beginning in a leg, accompanied by fasciculations and muscle wasting from lower motor neuron involvement. Over time, upper motor neuron signs such as increased tone and brisk reflexes develop in affected regions, adding to the weakness. Sensation is typically preserved, so sensory loss is not a feature. Facial weakness can occur later if bulbar muscles are involved, but the hallmark initial finding is asymmetric limb weakness.

ALS often presents as a motor neuron disease with weakness that starts in one area and is not symmetric. The most typical early pattern is asymmetric limb weakness, commonly beginning in a leg, accompanied by fasciculations and muscle wasting from lower motor neuron involvement. Over time, upper motor neuron signs such as increased tone and brisk reflexes develop in affected regions, adding to the weakness. Sensation is typically preserved, so sensory loss is not a feature. Facial weakness can occur later if bulbar muscles are involved, but the hallmark initial finding is asymmetric limb weakness.