Anti-DM medications for weight loss: which class is associated with weight loss?

Anti-DM medications for weight loss: which class is associated with weight loss?

• A. Metformin
• B. DPP-4 inhibitors
• C. SGLT-2 inhibitors
• D. GLP-1 receptor agonists

Answer: (D)

GLP-1 receptor agonists stand out because they promote weight loss through central appetite suppression and slower gastric emptying. By acting on GLP-1 receptors in the brain, these medications increase feelings of fullness, which helps reduce caloric intake. They also slow how quickly the stomach empties, which prolongs satiety after meals. This combination often leads to meaningful weight reduction, in addition to improving blood glucose. Examples include liraglutide, semaglutide, exenatide, and dulaglutide. In contrast, metformin can cause only modest weight loss or be weight neutral, DPP-4 inhibitors are typically weight neutral, and SGLT-2 inhibitors do cause some weight loss due to urinary glucose excretion but generally to a lesser extent than GLP-1 receptor agonists.

GLP-1 receptor agonists stand out because they promote weight loss through central appetite suppression and slower gastric emptying. By acting on GLP-1 receptors in the brain, these medications increase feelings of fullness, which helps reduce caloric intake. They also slow how quickly the stomach empties, which prolongs satiety after meals. This combination often leads to meaningful weight reduction, in addition to improving blood glucose.

Examples include liraglutide, semaglutide, exenatide, and dulaglutide. In contrast, metformin can cause only modest weight loss or be weight neutral, DPP-4 inhibitors are typically weight neutral, and SGLT-2 inhibitors do cause some weight loss due to urinary glucose excretion but generally to a lesser extent than GLP-1 receptor agonists.