In primary nephrotic syndrome, other than proteinuria and low albumin, what is commonly observed?

In primary nephrotic syndrome, other than proteinuria and low albumin, what is commonly observed?

• A. Coagulopathy
• B. Hypercalcemia
• C. Leukocytosis
• D. Hypokalemia

Answer: (A)

Loss of anticoagulant proteins in the urine, especially antithrombin III, creates a hypercoagulable state in nephrotic syndrome. This makes thrombosis a common complication alongside the already present proteinuria and low albumin. Patients are at higher risk for venous clots such as renal vein or deep vein thrombosis. Hypercalcemia is not typical here; diarrhea, leukocytosis, or electrolyte shifts like hypokalemia aren’t defining features of this syndrome. The coagulopathy explanation ties together why clotting issues are a notable accompanying finding.

Loss of anticoagulant proteins in the urine, especially antithrombin III, creates a hypercoagulable state in nephrotic syndrome. This makes thrombosis a common complication alongside the already present proteinuria and low albumin. Patients are at higher risk for venous clots such as renal vein or deep vein thrombosis. Hypercalcemia is not typical here; diarrhea, leukocytosis, or electrolyte shifts like hypokalemia aren’t defining features of this syndrome. The coagulopathy explanation ties together why clotting issues are a notable accompanying finding.