In sepsis, what is the recommended maximum blood glucose target for intensive management in adults?

In sepsis, what is the recommended maximum blood glucose target for intensive management in adults?

• A. <110 mg/dL
• B. <180 mg/dL
• C. <200 mg/dL
• D. <150 mg/dL

Answer: (B)

In sepsis and other critical illnesses, the goal of blood glucose management is to avoid damaging hyperglycemia while minimizing the risk of hypoglycemia from too-tight control. Evidence shows that very strict glucose targets (like 80–110 mg/dL) do not improve outcomes and can increase mortality due to hypoglycemia. Current practice aims to keep glucose in a safer range, commonly around 140–180 mg/dL for most critically ill adults, including those with sepsis. Thus the recommended maximum target is keeping blood glucose under 180 mg/dL. This balance helps reduce hyperglycemia-associated risks without the dangers of aggressive insulin therapy. If glucose rises above 180 mg/dL, insulin may be adjusted to maintain within the 140–180 mg/dL range, with close monitoring to prevent hypoglycemia.

In sepsis and other critical illnesses, the goal of blood glucose management is to avoid damaging hyperglycemia while minimizing the risk of hypoglycemia from too-tight control. Evidence shows that very strict glucose targets (like 80–110 mg/dL) do not improve outcomes and can increase mortality due to hypoglycemia. Current practice aims to keep glucose in a safer range, commonly around 140–180 mg/dL for most critically ill adults, including those with sepsis. Thus the recommended maximum target is keeping blood glucose under 180 mg/dL. This balance helps reduce hyperglycemia-associated risks without the dangers of aggressive insulin therapy. If glucose rises above 180 mg/dL, insulin may be adjusted to maintain within the 140–180 mg/dL range, with close monitoring to prevent hypoglycemia.