In von Willebrand disease, how do FVIII levels typically change?

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Multiple Choice

In von Willebrand disease, how do FVIII levels typically change?

Explanation:
FVIII is normally stabilized and protected in the bloodstream by von Willebrand factor. When vWF is deficient or dysfunctional, FVIII isn’t shielded and is cleared from circulation more rapidly, so its plasma level drops. This reduction in FVIII contributes to the bleeding tendency seen in von Willebrand disease and can cause a longer aPTT. So the best description is that FVIII levels are decreased due to the lack of protection by vWF.

FVIII is normally stabilized and protected in the bloodstream by von Willebrand factor. When vWF is deficient or dysfunctional, FVIII isn’t shielded and is cleared from circulation more rapidly, so its plasma level drops. This reduction in FVIII contributes to the bleeding tendency seen in von Willebrand disease and can cause a longer aPTT. So the best description is that FVIII levels are decreased due to the lack of protection by vWF.

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