What is the greatest risk factor for developing osteoarthritis in older adults?

What is the greatest risk factor for developing osteoarthritis in older adults?

• A. Sedentary lifestyle
• B. Smoking
• C. Hypertension
• D. Obesity

Answer: (D)

Excess body weight stands out because it increases the load on weight-bearing joints—especially the knees and hips—and this mechanical stress accelerates cartilage wear over time. In addition, adipose tissue secretes inflammatory substances that can promote joint inflammation and cartilage breakdown, linking obesity to OA progression beyond just the physical load. Because this factor is both strong and modifiable, it has a larger impact on OA development and progression in older adults than other common factors like a sedentary lifestyle, smoking, or hypertension. Weight reduction and maintaining muscle strength around the joints can meaningfully reduce risk and slow disease progression.

Excess body weight stands out because it increases the load on weight-bearing joints—especially the knees and hips—and this mechanical stress accelerates cartilage wear over time. In addition, adipose tissue secretes inflammatory substances that can promote joint inflammation and cartilage breakdown, linking obesity to OA progression beyond just the physical load. Because this factor is both strong and modifiable, it has a larger impact on OA development and progression in older adults than other common factors like a sedentary lifestyle, smoking, or hypertension. Weight reduction and maintaining muscle strength around the joints can meaningfully reduce risk and slow disease progression.