What is the most common neurological complication of Paget's disease of the bone?

What is the most common neurological complication of Paget's disease of the bone?

• A. Hearing loss
• B. Seizures
• C. Peripheral neuropathy
• D. Dementia

Answer: (A)

Hearing loss is the most common neurological complication because Paget disease frequently involves the skull, especially the temporal bone. The abnormal bone remodeling thickens and deforms the surrounding structures, which can compress the cochlear and vestibulocochlear apparatus or impair the middle and inner ear, leading to conductive or sensorineural hearing loss. Seizures, peripheral neuropathy, and dementia can occur but are much less common and usually reflect more extensive skull involvement or other factors rather than a typical feature of Paget disease.

Hearing loss is the most common neurological complication because Paget disease frequently involves the skull, especially the temporal bone. The abnormal bone remodeling thickens and deforms the surrounding structures, which can compress the cochlear and vestibulocochlear apparatus or impair the middle and inner ear, leading to conductive or sensorineural hearing loss. Seizures, peripheral neuropathy, and dementia can occur but are much less common and usually reflect more extensive skull involvement or other factors rather than a typical feature of Paget disease.