Which agent used to reduce postpartum hemorrhage should be avoided in asthmatics due to risk of bronchospasm?

Which agent used to reduce postpartum hemorrhage should be avoided in asthmatics due to risk of bronchospasm?

• A. Oxytocin
• B. Misoprostol
• C. Carboprost
• D. Ergometrine

Answer: (C)

Carboprost is a prostaglandin F2alpha analog used to treat postpartum hemorrhage from uterine atony, but it can provoke bronchial smooth muscle contraction leading to bronchospasm. In patients with asthma, this risk makes carboprost contraindicated. Oxytocin is the first-line uterotonic and does not cause bronchospasm. Misoprostol (prostaglandin E1 analog) is generally safe in asthma and serves as an alternative when IV oxytocin isn’t available. Ergometrine mainly causes uterine and systemic vasoconstriction with other contraindications, not a primary bronchospasm risk. So the agent to avoid in asthmatics due to bronchospasm is carboprost.

Carboprost is a prostaglandin F2alpha analog used to treat postpartum hemorrhage from uterine atony, but it can provoke bronchial smooth muscle contraction leading to bronchospasm. In patients with asthma, this risk makes carboprost contraindicated. Oxytocin is the first-line uterotonic and does not cause bronchospasm. Misoprostol (prostaglandin E1 analog) is generally safe in asthma and serves as an alternative when IV oxytocin isn’t available. Ergometrine mainly causes uterine and systemic vasoconstriction with other contraindications, not a primary bronchospasm risk. So the agent to avoid in asthmatics due to bronchospasm is carboprost.