Which antibiotic has antipseudomonal activity and would be most appropriate for such puncture wounds?

Which antibiotic has antipseudomonal activity and would be most appropriate for such puncture wounds?

• A. Ciprofloxacin
• B. Amoxicillin
• C. Doxycycline
• D. Clavulanic acid

Answer: (A)

Pseudomonas infection is a key concern with puncture wounds, especially those through shoe leather, so choosing an antibiotic with reliable antipseudomonal activity for outpatient oral therapy is important. Ciprofloxacin is a fluoroquinolone with strong activity against Pseudomonas aeruginosa, making it the best option for these wounds when oral treatment is appropriate. Amoxicillin alone has limited activity against Pseudomonas. Amoxicillin–clavulanate broadens coverage for some bacteria but does not reliably cover Pseudomonas. Doxycycline lacks dependable antipseudomonal activity for this scenario. Clavulanic acid by itself has no antimicrobial effect—it’s a beta-lactamase inhibitor used with other antibiotics, not a stand-alone agent. So the agent with true antipseudomonal coverage suitable for treating such puncture wounds is ciprofloxacin.

Pseudomonas infection is a key concern with puncture wounds, especially those through shoe leather, so choosing an antibiotic with reliable antipseudomonal activity for outpatient oral therapy is important. Ciprofloxacin is a fluoroquinolone with strong activity against Pseudomonas aeruginosa, making it the best option for these wounds when oral treatment is appropriate.

Amoxicillin alone has limited activity against Pseudomonas. Amoxicillin–clavulanate broadens coverage for some bacteria but does not reliably cover Pseudomonas. Doxycycline lacks dependable antipseudomonal activity for this scenario. Clavulanic acid by itself has no antimicrobial effect—it’s a beta-lactamase inhibitor used with other antibiotics, not a stand-alone agent.

So the agent with true antipseudomonal coverage suitable for treating such puncture wounds is ciprofloxacin.