Which antidepressant has consistent evidence for improving depressive symptoms in children and adolescents?

Which antidepressant has consistent evidence for improving depressive symptoms in children and adolescents?

• A. Sertraline
• B. Citalopram
• C. Paroxetine
• D. Fluoxetine

Answer: (D)

Fluoxetine has the strongest and most consistent evidence for improving depressive symptoms in children and adolescents. Multiple randomized controlled trials show reliable improvement in pediatric major depressive disorder with fluoxetine, and it is FDA-approved for use in youths (typically ages 8–18). This solid evidence base sets it apart from other antidepressants, which have more limited or inconsistent data for pediatric MDD and, in some cases (like paroxetine), safety concerns in youth. In practice, guidelines often position fluoxetine as a first-line pharmacotherapy option alongside psychotherapy, with careful monitoring for adverse effects and suicidality.

Fluoxetine has the strongest and most consistent evidence for improving depressive symptoms in children and adolescents. Multiple randomized controlled trials show reliable improvement in pediatric major depressive disorder with fluoxetine, and it is FDA-approved for use in youths (typically ages 8–18). This solid evidence base sets it apart from other antidepressants, which have more limited or inconsistent data for pediatric MDD and, in some cases (like paroxetine), safety concerns in youth. In practice, guidelines often position fluoxetine as a first-line pharmacotherapy option alongside psychotherapy, with careful monitoring for adverse effects and suicidality.