Which medication class is associated with hypercalcemia?

Which medication class is associated with hypercalcemia?

• A. ACE inhibitors
• B. Thiazide diuretics
• C. NSAIDs
• D. Beta-blockers

Answer: (B)

Calcium balance in the body is influenced by how kidneys handle calcium, and one drug class can tip this balance toward higher calcium levels by increasing calcium reabsorption in the distal nephron. Thiazide diuretics inhibit the Na-Cl cotransporter in the distal convoluted tubule, which not only reduces sodium reabsorption but also promotes calcium reabsorption. This effect decreases calcium loss in urine and can raise serum calcium, especially with long-term use or in susceptible individuals. That’s why thiazides are the class associated with hypercalcemia. Other common drug classes listed do not typically raise calcium levels.

Calcium balance in the body is influenced by how kidneys handle calcium, and one drug class can tip this balance toward higher calcium levels by increasing calcium reabsorption in the distal nephron. Thiazide diuretics inhibit the Na-Cl cotransporter in the distal convoluted tubule, which not only reduces sodium reabsorption but also promotes calcium reabsorption. This effect decreases calcium loss in urine and can raise serum calcium, especially with long-term use or in susceptible individuals. That’s why thiazides are the class associated with hypercalcemia. Other common drug classes listed do not typically raise calcium levels.