Which statement best describes the Shingrix vaccine compared with Zostavax?

Which statement best describes the Shingrix vaccine compared with Zostavax?

• A. Increased efficacy
• B. Equivalent efficacy
• C. Lower efficacy
• D. Requires more injections

Answer: (A)

Shingrix achieves higher efficacy because it is a recombinant zoster vaccine with a potent adjuvant, given as a two-dose series. This design provokes a stronger and more durable immune response than Zostavax, which is a live attenuated vaccine with lower and waning protection over time. The combination of a robust initial immune boost and the added durability across age groups, especially in older adults, explains why Shingrix provides increased efficacy compared with Zostavax.

Shingrix achieves higher efficacy because it is a recombinant zoster vaccine with a potent adjuvant, given as a two-dose series. This design provokes a stronger and more durable immune response than Zostavax, which is a live attenuated vaccine with lower and waning protection over time. The combination of a robust initial immune boost and the added durability across age groups, especially in older adults, explains why Shingrix provides increased efficacy compared with Zostavax.