Which statement is true regarding antibiotics for acute uncomplicated cystitis?

Which statement is true regarding antibiotics for acute uncomplicated cystitis?

• A. Fluoroquinolones are the first-line
• B. Amoxicillin only
• C. Trimethoprim-sulfamethoxazole (Bactrim) only
• D. Fluoroquinolones are not considered first-line due to increasing resistance and tendon rupture risk

Answer: (D)

Acute uncomplicated cystitis is treated with a short course of a narrow-spectrum oral antibiotic that is effective against the usual urine pathogens while minimizing resistance and side effects. Fluoroquinolones have fallen out of favor as first-line agents for this condition because resistance among community bacteria has risen and there are notable safety concerns, including the risk of tendon rupture and other adverse effects. That’s why the correct statement is that fluoroquinolones are not considered first-line due to increasing resistance and tendon rupture risk. First-line options typically include nitrofurantoin for about five days or trimethoprim-sulfamethoxazole if local resistance to TMP-SMX is low, with fosfomycin as another alternative. Amoxicillin is generally avoided because of high resistance rates.

Acute uncomplicated cystitis is treated with a short course of a narrow-spectrum oral antibiotic that is effective against the usual urine pathogens while minimizing resistance and side effects. Fluoroquinolones have fallen out of favor as first-line agents for this condition because resistance among community bacteria has risen and there are notable safety concerns, including the risk of tendon rupture and other adverse effects. That’s why the correct statement is that fluoroquinolones are not considered first-line due to increasing resistance and tendon rupture risk.

First-line options typically include nitrofurantoin for about five days or trimethoprim-sulfamethoxazole if local resistance to TMP-SMX is low, with fosfomycin as another alternative. Amoxicillin is generally avoided because of high resistance rates.