Why are second-generation H1 antihistamines preferred for acute urticaria?

Why are second-generation H1 antihistamines preferred for acute urticaria?

• A. They have longer duration and less drowsiness
• B. They act faster but are more sedating
• C. They are less effective but cheaper
• D. They cause more drowsiness

Answer: (A)

Second-generation H1 antihistamines are favored for acute urticaria because they provide lasting relief from itching and wheals while causing minimal drowsiness. This comes from their limited ability to cross into the central nervous system and their more selective peripheral action, which reduces sedation and anticholinergic side effects. The result is longer-lasting effects with typically once-daily dosing, allowing patients to function normally during the day. In contrast, first-generation agents are more sedating and can impair alertness, making them less suitable for acute urticaria.

Second-generation H1 antihistamines are favored for acute urticaria because they provide lasting relief from itching and wheals while causing minimal drowsiness. This comes from their limited ability to cross into the central nervous system and their more selective peripheral action, which reduces sedation and anticholinergic side effects. The result is longer-lasting effects with typically once-daily dosing, allowing patients to function normally during the day. In contrast, first-generation agents are more sedating and can impair alertness, making them less suitable for acute urticaria.